2-Hydroxy-5-methylpyridine - Names and IdentifiersName2-Hydroxy-5-methylpyridineSynonymsAKOS BB
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| Nama | 2-Hydroxy-5-methylpyridine |
| Sinonim | AKOS BBS-00002970 5-Methyl-2-pyridinol 6-HYDROXY-3-PICOLINE 5-METHYL-2-PYRIDINOL 5-METHYL-PYRIDIN-2-OL 2-Pyridinol,5-methyl- 5-METHYLPYRIDINE-2-ONE 5-METHYL-2(1H)PYRIDONE 5-methyl-(1H)pyridinone 5-Methyl 2-(1H)pyridinone 5-methylpyridin-2(1H)-one 5-Methyl-2(1H)pypridinone 5-METHYL-2(1H)-PYRIDINONE 5-METHYL-2(1H)PYPRIDINONE 4-methylpyridin-2(1H)-one 5-Methyl-2-(1H)pyridinone 2-Hydroxy-5-methylpyridine 5-Methyl-2-hydroxypyridine |
| CAS | 1003-68-5 91914-06-6 |
| EINECS | 213-713-9 |
| InChI | InChI=1/C6H7NO/c1-5-2-3-7-6(8)4-5/h2-4H,1H3,(H,7,8) |
| InChIKey | SOHMZGMHXUQHGE-UHFFFAOYSA-N |
| Rumus Molekuler | C6H7NO |
| Massa Molar | 109.13 |
| Kepadatan | 1.053±0.06 g/cm3(Predicted) |
| Titik Melting | 183-187 °C (lit.) |
| Titik Boling | 304.2±15.0 °C(Predicted) |
| Titik Flash | 170.6 °C |
| Solubilitas | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| Tekanan Vapor | 0mmHg di 25°C |
| Penampilan | White to brown powder or crystal |
| warna | Pale Yellow to Light Yellow |
| BRN | 107074 |
| pKa | 12.43±0.10(Predicted) |
| Kondisi penyimpanan | Terkunci dalam kering,Suhu Kamar |
| Indeks Refraksi | 1.551 |
| MDL | MFCD03092888 |
| Sifat fisik dan kimia |
| Simbol Bahaya | Xn - Berbahaya |
| Kode Risiko | Please take the official translations! You find them here: http: // europa. eu. int/ eur- lex/ lex/ LexUriServ/ LexUriServ. do? uri=CELEX: 32001L0059: EN: HTML R37/38 - Mengganggu sistem respirasi dan kulit. Please take the official translations! You find them here: http: // europa. eu. int/ eur- lex/ lex/ LexUriServ/ LexUriServ. do? uri=CELEX: 32001L0059: EN: HTML R36/37/39 - |
| Deskripsi Keselamatan | S26 - Jika kontak dengan mata, bilas segera dengan banyak air dan minta saran medis. S36 - Pakai pakaian pelindung yang sesuai. S37 - Wear suitable gloves. |
| WGK Jerman | 3 |
| Kode HS | 29333990 |
| Informasi kimia NIST | Informasi yang disediakan oleh: webbook.nist.gov (link eksternal) |
| Aplikasi | 2-hydroxy-5-methylpyridine is a pharmaceutical intermediate that can be used to prepare pirfenidone. Pirfenidone is a new pyridone compound with broad-spectrum anti-fibrosis effect, which is a white or light yellow crystalline powder. It can prevent and reverse the formation of fibrosis and scars; and the drug also has a good effect in renal interstitial fibrosis, liver fibrosis and other fibrotic diseases; at the same time, it is also used in kidney disease (focal segmental glomerulosclerosis), Hypertrophic cardiomyopathy, adult type I multiple neurofibroma, adolescent type I multiple neurofibroma and plexiform neurofibroma, diabetes with kidney disease, uterine leiomyoma and other phase II clinical studies have a wide range of applications. |
| persiapan | (1) mix 2-amino -5-methylpyridine, diazotization reagent and water evenly, cool to -4 ℃-3 ℃, add acidic solution for heat preservation reaction; After the reaction is complete, heat hydrolysis and cooling, and then adjust the pH to 6.5-7.5 with a mass fraction of 30% sodium hydroxide solution, the organic phase is extracted by the first solvent, dried and concentrated under reduced pressure to obtain 2-hydroxy-5-methylpyridine crude product;(2) A second solvent is added to the 2-hydroxy-5-methylpyridine crude product, heated and refluxed, cooled and crystallizated, pumped and dried to produce 2-hydroxy-5-methylpyridine pure product. |
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